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2008-04-18 iPS細胞

by Kiryu Hisanori last modified 2008-04-18 21:09

iPS細胞を使ってパーキンソン病を模したラットを治療するという研究の紹介。

Generation of germline-competent induced pluripotent stem cells.

Okita K, Ichisaka T, Yamanaka S
Nature, 448(7151):313-7, 2007 Jul

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S
Nat Biotechnol, 26(1):101-6, 2008 Jan

Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S
Cell, 131(5):861-72, 2007 Nov

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.

Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R
Proc Natl Acad Sci U S A, 2008 Apr

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