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Evaluation

We have evaluated the prediction performance of miRRim by plotting the number of total predictions in the human genome (X-axis) and the number of known miRNA detacted (Y-axis). In figure 1, the prediction performances of miRRim as well as Berezikov et al. (2005), miRNAMap 1.0 (Hsu et al. 2006), RNAmicro 1.1 (Hertel and Stadler 2006), and Li et al. (2006) are shown. With miRRim, the total number of predictions was smaller than those of the other methods when the coverage was the same. The exact numbers and genomic coordinates of miRNAs predicted by miRRim are shown in http://mirrim.ncrna.org/TableS1.html. For more details, see Terai et al. (2007).

fig1.PNG

Figure 1 Number of miRNA detected and total number of predictions

Reference

Phylogenetic shadowing and computational identification of human microRNA genes.
Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E
Cell 120(1):21-4, 2005 Jan

miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes.
Hsu PW, Huang HD, Hsu SD, Lin LZ, Tsou AP, Tseng CP, Stadler PF, Washietl S, Hofacker IL
Nucleic Acids Res 34(Database issue):D135-9, 2006 Jan

Hairpins in a Haystack: recognizing microRNA precursors in comparative genomics data.
Hertel J, Stadler PF
Bioinformatics 22(14):e197-202, 2006 Jul

Bioinformatic discovery of microRNA precursors from human ESTs and introns.
Li SC, Pan CY, Lin WC
BMC Genomics 7:164, 2006, Epub 2006 Jul

miRRim: a novel system to find conserved miRNAs with high sensitivity and specificity.
Terai G, Komori T, Asai K, Kin T
RNA 13(12):2081-90, 2007 Dec, Epub 2007 Oct


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